CJC-1295.INFO explains a long-acting growth hormone releasing peptide. We do not sell anything.
CJC-1295
.INFO
The Evidence

What the Research Shows

Context: All human data come from short studies in healthy volunteers published in 2006 and 2009. No study has shown a health benefit from CJC-1295 in any patient group.

The published research on CJC-1295 is small. It covers animal experiments, two short trials in healthy people and a growing number of anti-doping studies.

Animal Studies

  • Rats (Endocrinology, 2005): CJC-1295 resisted DPP-4, released four times more growth hormone than GHRH(1-29) and was found bound to albumin in blood for over 24 hours.
  • Mice without GHRH (Am J Physiol, 2006): mice bred to lack their own GHRH grew to normal weight and length when given CJC-1295 once a day for five weeks. Doses every two or three days helped less. The pituitary glands showed more growth hormone producing cells.

Studies in Healthy Adults

  • Duration (J Clin Endocrinol Metab, 2006): after one injection, average growth hormone rose two- to tenfold for six days or more, and IGF-I rose 1.5- to threefold for nine to eleven days. The estimated half-life was 5.8 to 8.1 days. With repeated doses, IGF-I stayed above baseline for up to 28 days. No serious adverse reactions were reported.
  • Pulse pattern (J Clin Endocrinol Metab, 2006): in young men sampled every 20 minutes overnight, growth hormone pulses kept their usual number and size. The levels between pulses rose about 7.5-fold, mean growth hormone by 46% and IGF-I by 45%.
  • Blood proteins (Growth Horm IGF Res, 2009): in 11 young men, a week after an injection, several blood proteins changed. The authors proposed them as possible markers of growth hormone activity.

Anti-Doping Research

A 2021 review from King's College London noted that GHRH analogues had apparently not been found in official anti-doping samples, even though there was evidence of their use. The authors studied how CJC-1295, with and without DAC, breaks down and built a urine test whose detection limits were generally at or below WADA's required level of 1 nanogram per millilitre.

Gaps in the Evidence

  • No results have been published from trials in patients.
  • The longest published human study lasted 49 days.
  • Several key papers were written with scientists from the developing company.
  • A 2026 review of unapproved peptides in sports medicine judged rigorous human safety data to be scarce.

Bottom Line

CJC-1295 reliably raises growth hormone and IGF-I for days in healthy adults. Whether that leads to any meaningful benefit, and how safe it is over months, has never been shown.

References

  1. Jetté L, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146:3052-3058. PMID 15817669
  2. Teichman SL, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91:799-805. PMID 16352683
  3. Alba M, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291:E1290-E1294. PMID 16822960
  4. Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006;91:4792-4797. PMID 17018654
  5. Sackmann-Sala L, et al. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009;19:471-477. PMID 19386527
  6. Henninge J, et al. Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation. Drug Test Anal. 2010;2:647-650. PMID 21204297
  7. Van Hout MC, Hearne E. Netnography of female use of the synthetic growth hormone CJC-1295: pulses and potions. Subst Use Misuse. 2016;51:73-84. PMID 26771670
  8. Memdouh S, et al. Advances in the detection of growth hormone releasing hormone synthetic analogs. Drug Test Anal. 2021;13:1871-1887. PMID 34665524
  9. Mendias CL, Awan TM. Safety and efficacy of approved and unapproved peptide therapies for musculoskeletal injuries and athletic performance. Sports Med. 2026;56:1921-1935. PMID 41966639
  10. ConjuChem. A study to evaluate CJC 1295 in HIV patients with visceral obesity. ClinicalTrials.gov NCT00267527.